TV The Megan Mullally Show The Megan Mullally Show 4.2/10 by 5 users Two-time Emmy Award-winner Megan Mullally, coming off eight seasons as wisecracking socialite Karen Walker on NBC's "Will & Grace," moves into the driver's seat as host for this daytime talk show. Each episode is an entertaining hour featuring a mix of celebrities, real people, music, and comedy. Megan will interview top celebrities and also introduce the world to guests of all kinds — from quirky characters to funny kids to offbeat experts. Details Casts Posters Images Title The Megan Mullally Show Alternative Titles First Air Date 2006-09-18 Last Air Date 2007-01-24 Number of Episodes 76 Number of Seasons 1 Genres Talk, Networks TBS, Syndication, Casts Megan Mullally, Bret Simmons Plot Keywords musical, studies, disguise, unhappiness, boys' school, woman director, Self - Host Megan Mullally Self - Music Director / Keyboardist Bret Simmons